AntiMax-2- is a nano-emulsion of the following components:
- Sorbitan trioleate in squalene oil (5% v/v)
- Tween 80 in sodium citrate buffer (10 mM, pH 6.5)
It promotes a significant increase in antibody titers with reportedly more balanced Th1/Th2 responses than those obtained with alum.
AntiMax-2 is believed to act through a depot effect, enhancement of antigen persistence at the injection site, recruitment and activation of antigen presenting cells, and direct stimulation of cytokines and chemokines production by macrophages and granulocytes.