AntiMax-4 is a nano-emulsion of 3 components:
- Sorbitan trioleate in squalene oil (5% v/v)
- Tween 80 in sodium citrate buffer (10 mM, pH 6.5)
- Poly[di(sodiumcarboxylatoethylphenoxy)phosphazene] (PCEP)
It promotes a significant increase in antibody titers with reportedly more balanced Th1/Th2 responses than those obtained with alum.
AntiMax-4 is believed to act through a depot effect, enhancement of antigen persistence at the injection site, recruitment and activation of antigen presenting cells, and direct stimulation of cytokines and chemokines production by macrophages and granulocytes'.